Find klebsiella pneumoniae stock images in hd and millions of other royalty free stock photos, illustrations and vectors in the shutterstock collection. Esblproducing escherichia coli and klebsiella pneumoniae at a tertiary. Jun 10, 2019 klebsiella granulomatis formerly calymmatobacterium granulomatis is a fastidious member of the genus that causes chronic genital ulcerative disease also known as granuloma inguinale or donovanosis. One of the resistance genes located in the plasmid is esbl coding gene. Yet, to know which genes encode esbl in nigeria, and to know exact. To our knowledge, it is the first report about a ctxm1 enzyme produced by a klebsiella pneumoniae subsp. Worldwide prevalence of antibiotic resistance in the bacteria. Other articles where klebsiella pneumoniae is discussed. Carbapenemase phenotype was only observed among the burn isolates but kpc type gene was not detected. Risk factors for infection by extendedspectrum betalactamase producing klebsiella pneumoniae in a tertiary hospital in salvador, brazil. Klebsiella pneumoniae is a gramnegative, nonmotile, encapsulated, lactose fermenting, facultative anaerobic, rodshaped bacterium. It is known as a pathogen that attacks hospitalized patients at a higher frequency and needds good antibiotic treatment. Feb 06, 2018 klebsiella is a type of bacteria commonly found in nature.
The antimicrobial susceptibility of klebsiella pneumoniae. Herein, we analyzed risk factors and prognosis in invasive infections caused by kp versus ec, in an area with low antimicrobial resistance. Twelve esbl ampcproducing klebsiella pneumoniae esbl ampckp were isolated from 3. Molecular epidemiology of extendedspectrum betalactamase. Klebsiella pneumoniae, a member of the fa mily enterobacteriac eae, is a rodshap ed, gramnegative, lactosefermentin g bacillus wit h a prominent capsule. A comparison of extendedspectrum betalactamase esblproducing escherichia coli and klebsiella pneumoniae bloodstream infections in alberta using a provincial surveillance system kathryn r. Klebsiella pneumoniae has been a leading health careacquired infection hai agent for decades 1, 2. Esbl is an enzyme produced by gramnegative bacillus bacteria that can hydrolyze.
Pdf to better understand the clinical outcomes of patients with. From may 2002 to august 2010, clinical information and outcome of adults with bacteremic pneumonia caused by esbl producing escherichia coli and klebsiella pneumoniae were analyzed. Pdf infections caused by extendedspectrum betalactamase esbl producing pathogens, particularly klebsiella pneumoniae, are increasing. Invasive infection caused by klebsiella pneumoniae is a. Esblproducing escherichia coli and klebsiella pneumoniae.
To study whether extendedspectrum blactamase esbl producing k. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmidencoded antibiotic resistance. Due to the importance of drugresistant klebsiella pneumoniae and escherichia coli strains in hospitalacquired infections, we aimed to determine the phenotypic and genotypic characteristics of esbl, ampc, and carbapenemaseproducing isolates obtained from hospitalized patients in tehran and ilam iran. Antibacterial disinfecting and cleaning all in one 99. In the united states, klebsiella pneumoniae and klebsiella oxytoca are the two strains responsible for most human. Survey of esbl producing escherichia coli and klebsiella. Secular trends in klebsiella pneumoniae isolated in a. Bacteremic pneumonia caused by extendedspectrum beta. Twelve esblampcproducing klebsiella pneumoniae esblampckp were. Klebsiella pneumoniae is a significant enterobacteriaceae considered as one of the opportunistic pathogens causing broad spectra of diseases and showing increasingly frequent acquisition of resistance to antibiotics. Pdf molecular pathogenesis of klebsiella pneumoniae. Original article esblproducing escherichia coli and.
Klebsiella pneumoniae in healthcare settings hai cdc. Health, general antibacterial agents bacterial pneumonia genetic aspects beta lactamases drug resistance in microorganisms gene mutation gene mutations microbial drug resistance pneumonia. The amplification of a ctxm class enzymeencoding gene confirmed such a phenotype, and sequencing of the gene identified the bla ctxm1 group. Survey of esbl producing escherichia coli and klebsiella pneumoniae and mrsa in a tertiary care facility in united arab emirates. Antimicrobial susceptibility testing and whole genome sequencing analysis were used to characterise antimicrobial resistance genes carried by the bacteria. Pdf extended spectrum lactamaseproducing klebsiella. Health, general bacterial pneumonia cross infection dna sequencing drug resistance in microorganisms genomics hospital patients microbial drug resistance nosocomial infections nucleotide sequencing phylogeny pneumonia public health. Treatment of esblproducing klebsiella pneumoniae bacteraemia. The aim of this study was to characterize esblproducing k. A retrospective study was conducted at two medical centers in taiwan. Klebsiella pneumoniae are increasingly common due to betalactamases resistant to penicillin and ampicillin. Lactamase esblproducing enterobacteriaceae considerations for diagnosis, prevention and drug treatment mark e. Furthermore, the bacteria belong to the esbl producing strains esbl extendedspectrum betalactamase and are therefore increasingly common multiresistant to many broadacting antibiotics such as cephalosporins or ceftazidime.
Drugresistant klebsiella pneumoniae, especially extendedspectrum. Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary tract infections, bacteremias, and liver abscesses. Esblproducing klebsiella pneumoniae were evaluated against nonbetalactam. Risk of infection and carriage rates of klebsiella spp. Incidence of extendedspectrum betalactamaseproducing. Extendedspectrum betalactamases esbls are enzymes that confer increased.
In this study, we investigated the presence of esblampcproducing klebsiella spp. Phylogenetic analysis of klebsiella pneumoniae from. Klebsiella is a bacteria that can cause different types of infections such as a urinary tract infection or pneumonia, and is considered a not very common pathogen among patients in the community meaning outside the hospital. It appears as a mucoid lactose fermenter on macconkey agar. As a free living diazotroph, its nitrogen fixation system has been much studied. In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. Extendedspectrum betalactamaseproducing escherichia coli and klebsiella pneumoniae from companion animals and horses and their putative impact on public health. Klebsiella pneumoniae is a ubiquitous gramnegative encapsulated bacterium that resides in the mucosal surfaces of mammals and the environment soil, water, etc. Klebsiella pneumoniae is a nosocomial pathogen commonly isolated from the intensive care unit icu and implicated in hospital outbreaks, which is increasingly displaying high drugresistant profiles through. Drug resistance among gramnegative bacteria is a worldwide challenge. Pdf variants of the klebsiella pneumoniae okp chromosomal. Medical laboratory manual for wortheinemann ltd, oxford. Extended spectrum beta lactamase esbl is a plasmid enzyme that mediates the occurrence of hydrolysis. Carbapenemase phenotype was only observed among the burn isolates but kpctype gene was not detected.
A study was designed to investigate the molecular epidemiology of extendedspectrum. Klebsiella pneumoniae a medical dictionary, bibliography, and annotated research guide to internet references icon health publications on. Variants of the klebsiella pneumoniae okp chromosomal betalactamase are divided into two main groups, okpa and okpb article pdf available in antimicrobial agents and chemotherapy 4912. Klebsiella pneumoniae is one of such clinically significant organisms that have acquired much public health concern. Enterobacteriaceae, esbl, escherichia coli, klebsiella pneumoniae, nigeria. Esblproducing escherichia coli and klebsiella pneumoniae at a tertiary care hospital in saudi arabia. Pdf infections caused by extendedspectrum betalactamase esblproducing pathogens, particularly klebsiella pneumoniae, are increasing. This study aimed to perform an investigation of extended.
Klebsiella pneumoniae kp is after escherichia coli ec the most common gramnegative species causing invasive infections. Phenotypic and genotypic characterization of esbl, ampc. Klebsiella pneumoniae is one of the most important human bacterial pathogens with an extensive range of community and hospital acquired infections that may lead to morbidity and mortality. Esblproducing strain of hypervirulent klebsiella pneumoniae. The prevalence of extendedspectrum betalactamase esbl positive klebsiella pneumoniae is growing worldwide.
Fecal colonization by extendedspectrum betalactamaseproducing klebsiella pneumoniae in a neonatal intensive care unit. Klebsiella pneumoniae is an important multidrugresistant mdr pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. Increasingly, klebsiella bacteria have developed antimicrobial resistance, most recently to the class of antibiotics known as carbapenems. Results here, we report the detection of klebsiella pneumoniae subspecies pneumoniae carrying the bla oxa48 gene on an incompatibility group lm plasmid from an infection in a common seal. A comparison of extendedspectrum betalactamase esbl. Clinical and laboratory profile of urinary tract infections associated. Feb 20, 2005 klebsiella pneumoniae ranks high as a cause of adult pneumonia requiring hospitalization in malaysia. Fey department of internal medicine, university of nebraska medical center, omaha, nebraska, usa. Klebsiella pneumoniae, also called friedlanders bacillus, was first described in 1882 by german microbiologist and pathologist carl friedlander.
Klebsiella pneumoniae definition of klebsiella pneumoniae. Multidrugresistant esblampcproducing klebsiella pneumoniae. Resistance to carbapenems and other antibiotics in. Although found in the normal flora of the mouth, skin, and intestines, it can cause destructive changes to human and animal lungs if aspirated. Klebsiella pneumoniae a medical dictionary, bibliography. Other tests showed that there was persontoperson spread of these antibioticresistant bacteria. Klebsiella pneumoniae is mainly responsible for hospitalacquired urinary tract infections, bacteremia, pneumonia and intraabdominal infections. Klebsiella pneumoniae, a common gut bacteria, causes problems when it moves outside the gut and causes infection. Klebsiella pneumoniae carbapenemase kpc, oxacillinase 48 oxa48, and new delhi metallo. Amikacin was outstanding among antimicrobials because of its high and stable rates of k. Klebsiella infection genetic and rare diseases information. Thirty percent of such infections acquired during hospitalization and 43% of infections acquired in the intensive care unit were esbl producing. Esblproducing escherichia coli and klebsiella pneumoniae in two major lebanese hospitals.
In northern france, the proportion of klebsiella pneumoniae isolates which were esbl producing fell from 19. Infections with these bacteria are suspected to be related to increased mortality. Pdf treatment of esblproducing klebsiella pneumoniae. The results showed that esblampcproducing klebsiella pneumoniae esblampckp isolated from horses have coresistance to other. Klebsiella pneumoniae are normally harmless bacteria that live in your intestines and feces, but they can be dangerous in other parts of your body. Antimicrobial resistance profiling for 17 antimicrobials showed all esbl ampckp were multidrugresistant mdr. However, in recent years, augmentation of infection control interventions has been accompanied by a decrease in incidence of esbl producing klebsiella pneumoniae 7, 223. In india, high prevalence of esblproducing klebsiella pneumonia strains. Molecular characterization was done using isoelectric focusing, pcr and sequencing for bla ctxm, bla tem and bla shv. Management of extendedspectrum betalactamasepositive gram. To better understand the clinical outcomes of patients with extendedspectrum. Hospital outcomes of adult respiratory tract infections with. Research letters, letter to the editor by emerging infectious diseases. The disease is usually seen only in patients with underlying medical.
Phylogenetic analysis of klebsiella pneumoniae from hospitalized children, pakistan. Based on several researches, it is known that resistance gene from. Klebsiella pneumoniae new delhi metallo beta lactamase ndm1 carbapenem resistant. Secular trends in klebsiella pneumoniae isolated in a tertiarycare hospital.
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